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This Article Accepted manuscript (PDF) All Versions of this Article: JME-08-0156v1 42/4/283    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Banhegyi, G. Articles by Benedetti, A. Search for Related Content PubMed PubMed Citation Articles by Banhegyi, G. Articles by Benedetti, A.

G Banhegyi, Pathophysiology Experimental Medicine and public Health, University of Siena, Siena, Italy
M Csala, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
A Benedetti, Pathophysiology Experimental Medicine and public Health, University of Siena, Siena, 53100, Italy

Correspondence: Angelo Benedetti, Email: benedetti{at}unisi.it

Abstract

Hexose-6-phosphate dehydrogenase got into the focus of interest due to its role in the prereceptorial activation of glucocorticoids, which has been implicated in the pathomechanism of metabolic syndrome. Genetic observations, results gained in hexose-6-phosphate dehydrogenase knock-out mice and studies on differentiating adipocytes demonstrated the importance of the enzyme in metabolic regulation. A nutrient sensing function can be postulated for the enzyme, which links metabolism to endocrinology in the endoplasmic reticulum. This review provides an overview of recent developments concerning the enzyme and its impact on various branches of the intermediary metabolism that makes it an important subject for the research on obesity, diabetes and metabolic syndrome.