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This Article Accepted manuscript (PDF) All Versions of this Article: JME-08-0146v1 42/2/75    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Malumbres, M. Articles by Quereda, V. Search for Related Content PubMed PubMed Citation Articles by Malumbres, M. Articles by Quereda, V.

M Malumbres, Cell Division and Cancer, Centro Nacional de Investigaciones Oncologicas, Madrid, E-28029, Spain
V Quereda, Cell Division and Cancer, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain

Correspondence: Marcos Malumbres, Email: mmm{at}cnio.es

Abstract

The pituitary gland regulates diverse physiological functions, including growth, metabolism, reproduction, stress response and ageing. Early genetic models in the mouse taught us that the pituitary is highly sensitive to genetic alteration of specific cell cycle regulators such as the Retinoblastoma protein (pRB) or the cell cycle inhibitor p27Kip1. The molecular analysis of human pituitary neoplasias has now corroborated that cell cycle deregulation is significantly implicated in pituitary tumorigenesis. In particular, proteins involved in cyclin-dependent kinase (CDK) regulation or the pRB pathway are altered in nearly all of human pituitary tumors. Additional cell cycle regulators such as PTTG1/securin may have critical roles in promoting genomic instability in pituitary neoplasias. Recent experimental data suggest that these cell cycle regulators may have significant implications in the biology of putative progenitor cells and pituitary homeostasis. Understanding how cell cycle regulation controls pituitary biology may provide us with new therapeutic approaches against pituitary diseases.