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A Rickard, Steroid Receptor Biology, Prince Henry's Institute, Clayton, Australia
M Young, Steroid Receptor Biology, Prince Henry's Institute, Clayton, Australia

Correspondence: Amanda Rickard, Email: Amanda.Rickard{at}princehenrys.org

Abstract

The mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) are ligand-activated transcription factors that have important physiological and pathophysiological actions in a broad range of cell types including monocytes and macrophages. While glucocorticoids, cortisol and corticosterone have well described anti-inflammatory actions in both recruited and tissue resident macrophages, a role for the mineralocorticoid aldosterone in these cells is largely undefined. Emerging evidence, however, suggests that MR signalling may promote pro-inflammatory effects. This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on diseases involving inflammation, with a particular focus on cardiovascular disease.

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