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This Article Accepted manuscript (PDF) All Versions of this Article: JME-08-0111v1 42/1/67    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Li, R. Articles by Song, H. Search for Related Content PubMed PubMed Citation Articles by Li, R. Articles by Song, H.

R Li, shanghai, 200025, China
X Li, shanghai, China
L Shao, SHANGHAI, China
Z Wu, shanghai, China
W Du, shanghai, China
S Li, shanghai, China
S Zhao, State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrinology, Shanghai, China
K Chen, shanghai, China
M Chen, shanghai, China
H Song, shanghai, China

Correspondence: Rongying Li, Email: newliry{at}hotmail.com

Abstract

Although circulating ghrelin levels correlate inversely with adiposity at baseline, little is known about the effect of percent visceral adipose tissue value (PVATV) on ghrelin expression and secretion in response to fasting. Our study demonstrated that Ghrelin increased with 24 hr fasting in rats with the lowest PVATV(less than 6%), after 3 days in rats with intermediate PVATV(6%-9%) and 5 days in rats with the highest PVATV (greater than 9%). Ghrelin mRNA in stomach was increased after 3 days in low PVATV(5.8%) rats but not in high PVATV(14%) rats. Therefore both ghrelin secretion and mRNA were delayed in response to fasting in rats with increased visceral fat. In rats matched for PVATV but with different body weights the fasting induced increased ghrelin was similar, while in rats with different PVATV ghrelin secretion was different in response to fasting, even body weights were matched in two groups. These data suggested that it was the initial PVATV, not lean mass, was related to the pattern of plasma ghrelin in response to fasting in rats.