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S Ezzat, Ontario Cancer Institute,
S Asa, University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Ontario, Canada

Correspondence: Shereen Ezzat, Email: sezzat{at}mtsinai.on.ca

Abstract

In this review we cover the evidence implicating Ikaros as a key factor whose transcriptional actions and chromatin remodeling properties determine the fate of hypothalamic neuroendocrine and pituitary cell population expansion. We propose that the governing mechanisms involved in the regulation and action of Ikaros are of importance during developmental as well as neoplastic transitions.

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