HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Accepted manuscript (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Lu, C. Articles by Cheng, S.-y. PubMed PubMed Citation Articles by Lu, C. Articles by Cheng, S.-y.

C Lu, Lab of Mol Biology, National Cancer Institute, Bethesda, United States
S Cheng, Lab of Mol Biology, National Cancer Institute, Bethesda, 20892-4264, United States

Correspondence: Sheue-yann Cheng, Email: chengs{at}mail.nih.gov

Abstract

Peroxisome proliferator-activated receptors (PPARs) and thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily. They are ligand-dependent transcription factors that interact with their cognate hormone response elements in the promoters to regulate respective target gene expression to modulate cellular functions. While the transcription activity of each is regulated by their respective ligands, recent studies indicate that via multiple mechanisms PPARs and TRs cross-talk to affect diverse biological functions. Here we review recent advances in the understanding of the molecular mechanisms and biological impact of cross-talk between these two important nuclear receptors, focusing on their roles in adipogenesis and carcinogenesis.