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This Article Full Text Full Text (PDF) All Versions of this Article: JME-08-0123v1 43/3/81    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Cheng, C. Y Y Articles by Chow, B. K C PubMed PubMed Citation Articles by Cheng, C. Y Y Articles by Chow, B. K C

School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China

(Correspondence should be addressed to B K C Chow; Email: bkcc{at}hkusua.hku.hk)

^* *(C Y Y Cheng and J Y S Chu contributed equally this work)

The maintenance of body water homeostasis depends on the balance between water intake and water excretion. In the kidney, vasopressin (Vp) is a critical regulator of water homeostasis by controlling the insertion of aquaporin 2 (AQP2) onto the apical membrane of the collecting duct principal cells in the short term and regulating the gene expression of AQP2 in the long term. A growing body of evidence from both in vitro and in vivo studies demonstrated that both secretin and oxytocin are involved as Vp-independent mechanisms regulating the renal water reabsorption process, including the translocation and expression of AQP2. This review focuses on how these two hormones are potentially involved as Vp-independent mechanisms in controlling water homeostasis.