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¹ Prince Henry's Institute of Medical Research, Clayton, 3168 Victoria, Australia² Department of Physiology, Monash University, Clayton, 3800 Victoria, Australia

(Correspondence should be addressed to A J Rickard; Email: amanda.rickard{at}princehenrys.org)

The mineralocorticoid receptor (MR) and glucocorticoid receptor are ligand-activated transcription factors that have important physiological and pathophysiological actions in a broad range of cell types including monocytes and macrophages. While the glucocorticoids cortisol and corticosterone have well-described anti-inflammatory actions on both recruited and tissue resident macrophages, a role for the mineralocorticoid aldosterone in these cells is largely undefined. Emerging evidence, however, suggests that MR signalling may promote pro-inflammatory effects. This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on diseases involving inflammation, with a particular focus on cardiovascular disease.

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