Journal of Molecular Endocrinology (2009) 42 185-190 DOI: 10.1677/JME-08-0150
© 2009 Society for Endocrinology
How to study lipidomes
Tuulikki Seppänen-Laakso and
Matej Ore
i
VTT Technical Research Centre of Finland, PO Box 1000 (Tietotie 2), Espoo FI-02044 VTT, Finland
(Correspondence should be addressed to M Ore
i
Email: matej.oresic{at}vtt.fi)
Lipidome is loosely defined as the entire spectrum of lipids in a biological system. Given the modern lipidomics platforms for the first time empower us with the ability to obtain a snapshot of complete cellular/organismal lipidome, many surprises and discoveries are likely awaiting us in the area of lipids as related to cellular/organismal physiology. The lipidomics approaches can be applied both as the phenotyping platform and for the hypothesis-driven research aiming to elucidate, e.g., a specific pathway or gene function. Modern lipidomics methods combine the latest mass spectrometry technology and bioinformatics methods with traditional methods such as for sample preparation and lipid extraction.
Copyright © 2009 by the Society for Endocrinology.