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¹ Department of Medicine² Department of Pathobiology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada M5G-1X5

(Correspondence should be addressed to S Ezzat who is now at Ontario Cancer Institute, 610 University Avenue, #8-327, Toronto, Ontario, Canada M5G-2M9; Email: shereen.ezzat{at}utoronto.ca)

The authors have nothing to disclose. The authors declare that there is no conflict of interest that would prejudice the impartiality of this scientific work.

In this review, we cover the evidence implicating Ikaros as a key factor whose transcriptional actions and chromatin remodeling properties determine the fate of hypothalamic neuroendocrine and pituitary cell population expansion. We propose that the governing mechanisms involved in the regulation and action of Ikaros are of importance during developmental as well as neoplastic transitions.

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