HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hurst, R. D. Articles by Morgan, N. G. Search for Related Content PubMed PubMed Citation Articles by Hurst, R. D. Articles by Morgan, N. G.

The mechanisms involved in inhibition of insulin secretion by somatostatin and noradrenaline were compared in order to establish whether the receptors for these agents are coupled to similar effector systems in the pancreatic B cell. Both agents significantly reduced forskolin-induced adenylate cyclase activity in islet homogenates, although noradrenaline was more effective than somatostatin. The capacity of noradrenaline to inhibit insulin secretion was largely unaffected by agents that increase intracellular cyclic AMP, whereas the effect of somatostatin as an inhibitor was markedly reduced under these conditions. Both noradrenaline and somatostatin inhibited the stimulation of insulin secretion induced by K⁺ depolarization, but different mechanism were involved. Somatostatin significantly inhibited K⁺-stimulated ⁴⁵Ca²⁺ efflux and influx in islets, while noradrenaline exerted only a minor influence on these processes. The data indicate that noradrenaline controls insulin secretion by a mechanism which operates beyond the level of intracellular messenger generation. In contrast, somatostatin exerts at least part of its inhibitory effect on insulin secretion by directly controlling islet cell Ca²⁺ influx in a manner which may be regulated by cyclic AMP.

This article has been cited by other articles:

				Y. Miura and H. Matsui Glucagon-like peptide-1 induces a cAMP-dependent increase of [Na+]i associated with insulin secretion in pancreatic {beta}-cells Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E1001 - E1009. [Abstract] [Full Text] [PDF]

				P. A Smith, L. A Sellers, and P. P A Humphrey Somatostatin activates two types of inwardly rectifying K+ channels in MIN-6 cells J. Physiol., April 1, 2001; 532(1): 127 - 142. [Abstract] [Full Text] [PDF]

				M. Gilligan, G. I. Welsh, A. Flynn, I. Bujalska, T. A. Diggle, R. M. Denton, C. G. Proud, and K. Docherty Glucose Stimulates the Activity of the Guanine Nucleotide-exchange Factor eIF-2B in Isolated Rat Islets of Langerhans J. Biol. Chem., January 26, 1996; 271(4): 2121 - 2125. [Abstract] [Full Text] [PDF]