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Departments of 1 Veterinary Physiology and Pharmacology and 2 Biochemistry and Biophysics,, Texas A & M University, College Station, Texas 77843-4466, USA 3 The Institute of Biosciences and Technology,, Texas A & M University Health Science Center, 2121 West Holcombe Boulevard, Houston, Texas 77030, USA
(Correspondence should be addressed to S Safe; Email: ssafe{at}cvm.tamu.edu)
The authors have nothing to disclose.
(RAR
) genes, RNA interference using small inhibitory RNAs for Sp1 (iSp1), Sp3 (iSp3), and Sp4 (iSp4) decreased both basal and E2-induced transactivation. The contributions of individual Sp proteins to basal and E2-induced activity were promoter dependent. iSp1, iSp3, and iSp4 also significantly inhibited hormonal induction of E2F1, CAD, and RAR
mRNA levels; however, the enhanced inhibitory effects of the latter two small inhibitory RNAs suggest that Sp3 and Sp4 play a major role in estrogen receptor
/Sp-mediated gene expression in MCF-7 cells.
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