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Journal of Molecular Endocrinology (2007) 39 17-28    DOI: 10.1677/JME-06-0054
© 2007 Society for Endocrinology
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A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum

 Laure Quignodon, Carmen Grijota-Martinez1, Emmanuel Compe2, Romain Guyot, Nathalie Allioli, David Laperrière4, Robert Walker3, Paul Meltzer3, Sylvie Mader4, Jacques Samarut and Frédéric Flamant

Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Université de Lyon, UMR INRA CNRS 5242, IFR128 46 allée d’Italie, 69364 Lyon Cedex 07, France
1 Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) and Center for Biomedical Research on Rare Diseases (CIBERER), 28029 Madrid, Spain
2 Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
3 Cancer Genetics Branch, NHGRI, Bethesda, Maryland, USA
4 Institut de recherche en Immunologie et Cancer, Université de Montréal, Montréal H3C3J7, Quebec, Canada

(Requests for offprints should be addressed to F Flamant; Email: frederic.flamant{at}ens-lyon.fr)

Thyroid hormones act directly on gene transcription in the post-natal developing cerebellum, controlling neuronal, and glial cell differentiation. We have combined three experimental approaches to identify the target genes that are underlying this phenomenon: 1) a microarray analysis of gene expression to identify hormone responsive genes in the cerebellum of Pax8–/– mice, a transgenic mouse model of congenital hypothyroidism; 2) a similar microarray analysis on primary culture of cerebellum neurons; and 3) a bioinformatics screen of conserved putative-binding sites in the mouse genome. This identifies surprisingly a small set of target genes, which, for some of them, might be key regulators of cerebellum development and neuronal differentiation.




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