| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Biologie du Développement et de la Reproduction – UMR 1198 INRA-ENVA, Bât. J Poly, 78350 Jouy-en-Josas, France
1 Physiologie de la Reproduction et des Comportements – UMR 6175 INRA-CNRS-Université de Tours, Haras Nationaux, 37380 Nouzilly, France
2 INSERM U709 Génomique et Epigénétique des Pathologies Placentaires (Ex. U361), Hôpital Cochin, Pavillon Baudelocque, 123 Bd de Port Royal, 75014 Paris, France
(Requests for offprints should be addressed to E Pailhoux; Email: eric.pailhoux{at}jouy.inra.fr)
* (S Fabre and F Batista contributed equally to this work)
Previous studies have equated FOXL2 as a crucial actor in the ovarian differentiation process in different vertebrate species. Its transcriptional extinction in the polled intersex syndrome (PIS) leads primarily to a drastic decrease of aromatase (CYP19) expression in the first steps of goat ovarian development. In this study, we provide a better characterization of early ovarian development in goat, and we provide experimental evidence demonstrating that FOXL2 represents a direct transcriptional activator of the CYP19 gene through its ovarian-specific promoter 2. Moreover, the ovarian location of FOXL2 and CYP19 proteins, together with their expression profiles in the female gonads, stress the involvement of FOXL2 co-factor(s) for regulating CYP19 transcription. Expressional analyses show that activin-ßA can be considered as a strong candidate for being one of these FOXL2 co-factors. Finally, we discuss evidence for a role of activin and estrogens in somatic and germinal cell proliferation occurring before germ cell meiosis. This period, of 20 days in goat, seems to have no equivalent in mouse. This species-specific difference could explain the phenotype discrepancy observed between XX goat PIS–/– and XX mouse Foxl2–/–.
This article has been cited by other articles:
|
|
 |
|
  S. P. Shah, M. Kobel, J. Senz, R. D. Morin, B. A. Clarke, K. C. Wiegand, G. Leung, A. Zayed, E. Mehl, S. E. Kalloger, et al. Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary N. Engl. J. Med., June 25, 2009; 360(26): 2719 - 2729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Blount, K. Schmidt, N. J. Justice, W. W. Vale, W. H. Fischer, and L. M. Bilezikjian FoxL2 and Smad3 Coordinately Regulate Follistatin Gene Transcription J. Biol. Chem., March 20, 2009; 284(12): 7631 - 7645. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Vizziano-Cantonnet, D. Baron, S. Mahe, C. Cauty, A. Fostier, and Y. Guiguen Estrogen treatment up-regulates female genes but does not suppress all early testicular markers during rainbow trout male-to-female gonadal transdifferentiation J. Mol. Endocrinol., November 1, 2008; 41(5): 277 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Andreu-Vieyra, R. Chen, and M. M. Matzuk Conditional Deletion of the Retinoblastoma (Rb) Gene in Ovarian Granulosa Cells Leads to Premature Ovarian Failure Mol. Endocrinol., September 1, 2008; 22(9): 2141 - 2161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Beysen, L. Moumne, R. Veitia, H. Peters, B. P. Leroy, A. De Paepe, and E. De Baere Missense mutations in the forkhead domain of FOXL2 lead to subcellular mislocalization, protein aggregation and impaired transactivation Hum. Mol. Genet., July 1, 2008; 17(13): 2030 - 2038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Fowler, N. J. Dora, H. McFerran, M. R. Amezaga, D. W. Miller, R. G. Lea, P. Cash, A. S. McNeilly, N. P. Evans, C. Cotinot, et al. In utero exposure to low doses of environmental pollutants disrupts fetal ovarian development in sheep Mol. Hum. Reprod., May 1, 2008; 14(5): 269 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Vizziano, D. Baron, G. Randuineau, S. Mahe, C. Cauty, and Y. Guiguen Rainbow Trout Gonadal Masculinization Induced by Inhibition of Estrogen Synthesis Is More Physiological Than Masculinization Induced by Androgen Supplementation Biol Reprod, May 1, 2008; 78(5): 939 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Moumne, A. Dipietromaria, F. Batista, A. Kocer, M. Fellous, E. Pailhoux, and R. A. Veitia Differential aggregation and functional impairment induced by polyalanine expansions in FOXL2, a transcription factor involved in cranio-facial and ovarian development Hum. Mol. Genet., April 1, 2008; 17(7): 1010 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Shoemaker, J. Queen, and D. Crews Response of Candidate Sex-Determining Genes to Changes in Temperature Reveals Their Involvement in the Molecular Network Underlying Temperature-Dependent Sex Determination Mol. Endocrinol., November 1, 2007; 21(11): 2750 - 2763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Liu, F. Wu, B. Jiao, X. Zhang, C. Hu, B. Huang, L. Zhou, X. Huang, Z. Wang, Y. Zhang, et al. Molecular cloning of doublesex and mab-3-related transcription factor 1, forkhead transcription factor gene 2, and two types of cytochrome P450 aromatase in Southern catfish and their possible roles in sex differentiation J. Endocrinol., July 1, 2007; 194(1): 223 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-S. Wang, T. Kobayashi, L.-Y. Zhou, B. Paul-Prasanth, S. Ijiri, F. Sakai, K. Okubo, K.-i. Morohashi, and Y. Nagahama Foxl2 Up-Regulates Aromatase Gene Transcription in a Female-Specific Manner by Binding to the Promoter as Well as Interacting with Ad4 Binding Protein/Steroidogenic Factor 1 Mol. Endocrinol., March 1, 2007; 21(3): 712 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Batista, D. Vaiman, J. Dausset, M. Fellous, and R. A. Veitia Potential targets of FOXL2, a transcription factor involved in craniofacial and follicular development, identified by transcriptomics PNAS, February 27, 2007; 104(9): 3330 - 3335. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
