| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
(Requests for offprints should be addressed to M S Roberson; Email: msr14{at}cornell.edu)
GnRH controls the synthesis and release of the pituitary gonadotropic hormones. MAP kinase (MAPK) cascades, including extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) pathways, are crucial for GnRH-induced gene activation. In the present study, we investigated the function of GnRH-induced MAPK phosphatases (MKPs) using an in vivo mouse model as well as the
T3–1 cell line. Following GnRH agonist stimulation, in vivo gene profiling demonstrated that both MKP-1 and MKP-2 are induced with distinct temporal profiles, suggesting differential roles of these MKPs in the regulation of MAPK activation. Elevated activity of MKP-2 in T3–1 cells, through either overexpression or activation of the endogenous MKP-2 gene, was correlated with inhibition of GnRH-induced activation of ERK and JNK, as well as the expression of ERK- and JNK-dependent proto-oncogenes. These data supported the conclusion that GnRH-induced MKPs likely serve as negative feedback regulators that modulate MAPK activity and function in the GnRH signaling pathway.
This article has been cited by other articles:
|
|
 |
|
  N. A. Ciccone, S. Xu, C. T. Lacza, R. S. Carroll, and U. B. Kaiser Frequency-Dependent Regulation of Follicle-Stimulating Hormone {beta} by Pulsatile Gonadotropin-Releasing Hormone Is Mediated by Functional Antagonism of bZIP Transcription Factors Mol. Cell. Biol., February 15, 2010; 30(4): 1028 - 1040. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. N. Purwana, H. Kanasaki, A. Oride, and K. Miyazaki Induction of Dual Specificity Phosphatase 1 (DUSP1) by Gonadotropin-Releasing Hormone (GnRH) and the Role for Gonadotropin Subunit Gene Expression in Mouse Pituitary Gonadotroph LbetaT2 Cells Biol Reprod, February 1, 2010; 82(2): 352 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Armstrong, C. J. Caunt, R. C. Fowkes, K. Tsaneva-Atanasova, and C. A. McArdle Pulsatile and Sustained Gonadotropin-releasing Hormone (GnRH) Receptor Signaling: DOES THE Ca2+/NFAT SIGNALING PATHWAY DECODE GnRH PULSE FREQUENCY? J. Biol. Chem., December 18, 2009; 284(51): 35746 - 35757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Armstrong, C. J. Caunt, and C. A. McArdle Gonadotropin-Releasing Hormone and Protein Kinase C Signaling to ERK: Spatiotemporal Regulation of ERK by Docking Domains and Dual-Specificity Phosphatases Mol. Endocrinol., April 1, 2009; 23(4): 510 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Walsh and M. A. Shupnik Proteasome Regulation of Dynamic Transcription Factor Occupancy on the GnRH-Stimulated Luteinizing Hormone {beta}-Subunit Promoter Mol. Endocrinol., February 1, 2009; 23(2): 237 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. I. Mayer, V. Dexheimer, E. Nishida, S. Kitajima, and G. Thiel Expression of the Transcriptional Repressor ATF3 in Gonadotrophs Is Regulated by Egr-1, CREB, and ATF2 after Gonadotropin-Releasing Hormone Receptor Stimulation Endocrinology, December 1, 2008; 149(12): 6311 - 6325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Salisbury, A. K. Binder, and J. H. Nilson Welcoming {beta}-Catenin to the Gonadotropin-Releasing Hormone Transcriptional Network in Gonadotropes Mol. Endocrinol., June 1, 2008; 22(6): 1295 - 1303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xie and M. S. Roberson 3', 5'-Cyclic Adenosine 5'-Monophosphate Response Element-Dependent Transcriptional Regulation of the Secretogranin II Gene Promoter Depends on Gonadotropin-Releasing Hormone-Induced Mitogen-Activated Protein Kinase Activation and the Transactivator Activating Transcription Factor 3 Endocrinology, February 1, 2008; 149(2): 783 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Iqbal, O. Latchoumanin, and I. J. Clarke Rapid in Vivo Effects of Estradiol-17{beta} in Ovine Pituitary Gonadotropes Are Displayed by Phosphorylation of Extracellularly Regulated Kinase, Serine/Threonine Kinase, and 3',5'-Cyclic Adenosine 5'-Monophosphate-Responsive Element-Binding Protein Endocrinology, December 1, 2007; 148(12): 5794 - 5802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Teng, W.-N. Huang, and T.-C. Meng Several Dual Specificity Phosphatases Coordinate to Control the Magnitude and Duration of JNK Activation in Signaling Response to Oxidative Stress J. Biol. Chem., September 28, 2007; 282(39): 28395 - 28407. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
