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Department of Neuroendocrinology, Institute of Basic Medical Sciences, University of Tsukuba, 1-1–1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan
¹ Department of Anatomy, School of Medicine, Keio University, Tokyo 160-8582, Japan

(Requests for offprints should be addressed to H Nogami; Email: hnogami{at}md.tsukuba.ac.jp)

Glucocorticoids are involved in the regulation of the rat growth hormone-releasing hormone (GHRH) receptor gene expression, but they act only in the presence of the pituitary specific transcription factor, pit-1. In this study, the role of pit-1 in the glucocorticoid stimulation of the GHRH-receptor gene transcription was examined. The results suggest the presence of a silencer element in the promoter and it is postulated that pit-1 permits glucocorticoid action through suppressing the inhibitory effect of an as yet unknown factor that binds to this element. The present results also suggest that the synergistic activation of the rat GHRH-receptor gene transcription depends on the proper distance between the proximal glucocorticoid response element and the pit-1 binding site.

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