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Journal of Molecular Endocrinology (2005) 34, 637-644    DOI: 10.1677/jme.1.01667
© 2005 Society for Endocrinology
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Suppressor of cytokine signalling (SOCS) genes are expressed in the endometrium and regulated by conceptus signals during early pregnancy in the ewe

Olivier Sandra, Isabelle Bataillon, Pascale Roux, Jacques Martal, Gilles Charpigny, Pierrette Reinaud, Philippe Bolifraud, Guy Germain and Kaïs H Al-Gubory

Institut National de la Recherche Agronomique, UMR 1198 INRA-ENVA Biologie du Développement et de la Reproduction, 78352 Jouy-en-Josas cedex, France

(Requests for offprints should be addressed to O Sandra; Email: olivier.sandra{at}jouy.inra.fr)

It is established that the conceptus–endometrium dialogue involves cytokines, growth factors and hormones. Given the crucial functions of the suppressor of cytokine signaling (SOCS) family proteins in cytokine signalling, we analyzed the expression and the regulation of CIS and SOCSs 1–3 transcripts during early pregnancy in the ovine endometrium. An overall stimulation of the SOCS transcripts was described in the pregnant ewes with two specific patterns. Unilaterally pregnant ewes confirmed the conceptus-produced factors as regulators of the SOCSs 1–3 expression at day 16 of pregnancy. Intrauterine injection of recombinant ovine interferon {tau} (IFN{tau}) in cyclic ewes stimulated the expression of the SOCS mRNA with various potencies, therefore suggesting that the SOCS could take part in the negative regulation of the IFN{tau} signalling pathway.




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T. E Spencer, O. Sandra, and E. Wolf
Genes involved in conceptus-endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches
Reproduction, February 1, 2008; 135(2): 165 - 179.
[Abstract] [Full Text] [PDF]


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