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School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, UK

(Requests for offprints should be addressed to J Bailey, School of Surgical and Reproductive Sciences (Obstetrics and Gynaecology), 3rd Floor, William Leech Building, Faculty of Medical Sciences, Framlington Place, Newcastle upon Tyne NE2 4HH, UK; Email: jarrod.bailey{at}ncl.ac.uk)

cAMP-response element (CRE) binding (CREB) and modulator (CREM) proteins, activated by protein kinase A-mediated phosphorylation, bind as homo- and heterodimers to promoters containing CRE and activator protein 1 (AP-1) sites to alter target-gene expression. We have previously reported differential expression of CREB and CREM splice variants CREM and CREM₂ in human myometrium during pregnancy and labour. Via microarray studies with cultured myometrial cells stably transfected with CREB, CREM and CREM₂ cDNAs, CREB affected the expression of 958 genes; 522 being up-regulated and 436 down-regulated. CREM altered the expression of 118 genes; 71 were increased and 47 decreased. CREM₂ affected 220 genes; 148 were activated and 72 repressed. Notably, genes affected by CREB, CREM and CREM₂ belong to largely discrete groups: less than 9% were affected by more than one factor. Genes involved in regulation of cell death and apoptosis, growth and maintenance, signal transduction, physiological and developmental processes, protein kinase cascades, extracellular matrix, cytoskeleton, cell-cycle regulation, transport, and a variety of enzymes, intracellular components and nucleic acid-binding proteins have been described, many of which are involved in the modulation of myometrial activity during pregnancy and parturition.

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