JME Society for Endocrinology Archive
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Molecular Endocrinology (2004) 33 763-771    DOI: 10.1677/jme.1.01529
© 2004 Society for Endocrinology
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Watanabe, H
Right arrow Articles by Iguchi, T
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Watanabe, H
Right arrow Articles by Iguchi, T

Comparative uterine gene expression analysis after dioxin and estradiol administration

H Watanabe1,2, A Suzuki1,2, M Goto1,2, S Ohsako2,3, C Tohyama2,3, H Handa4 and T Iguchi1,2

1 Center for Integrative Bioscience, Okazaki National Research Institutes, 5-1 Higashiyama, Myodaiji, Okazaki 444-8585, Japan
2 Core Research for Evolution Science and Technology (CREST), Japanese Science and Technology Corporation, Kawaguchi 332-0012, Japan
3 Environmental Health Sciences Division, National Institute for Environmental Studies, Onogawa, Tsukuba 305-8506, Japan
4 Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Yokohama, Kanagawa 226-8503, Japan

(Requests for offprints should be addressed to T Iguchi; Email: taisen{at}nibb.ac.jp)

The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) adversely affects many organisms. TCDD exposure is known to be associated with abnormal development, hepatotoxicity and endocrine effects. It has also been reported to have antiestrogenic activity in addition to estrogenic activity. In order to clarify the effects of TCDD in the uterus, we evaluated the patterns of gene expression after TCDD and estradiol administration. Of the 10 000 arrayed genes, only a few were affected by both estradiol and TCDD. Although the subset of genes that responded to estrogen was also activated by TCDD, the response to TCDD was more limited than that observed in response to estradiol. Therefore, according to our analysis of gene expression patterns, TCDD had partial and weak estrogenic activity in the uterus.




This article has been cited by other articles:


Home page
 Mol. Pharmacol.Home page
D. R. Boverhof, L. D. Burgoon, K. J. Williams, and T. R. Zacharewski
Inhibition of Estrogen-Mediated Uterine Gene Expression Responses by Dioxin
Mol. Pharmacol., January 1, 2008; 73(1): 82 - 93.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
D. R. Boverhof, J. C. Kwekel, D. G. Humes, L. D. Burgoon, and T. R. Zacharewski
Dioxin Induces an Estrogen-Like, Estrogen Receptor-Dependent Gene Expression Response in the Murine Uterus
Mol. Pharmacol., May 1, 2006; 69(5): 1599 - 1606.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Shimizu, R. Ouchida, N. Yoshikawa, T. Hisada, H. Watanabe, K. Okamoto, M. Kusuhara, H. Handa, C. Morimoto, and H. Tanaka
HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b
PNAS, June 14, 2005; 102(24): 8555 - 8560.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the Society for Endocrinology.