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Epididyme et Maturation des Gamètes, CNRS UMR 6547 GEEM, Université Blaise Pascal, 24, avenue des Landais, 63177 Aubière cedex, France
1 Physiologie Comparée et Endocrinologie Moléculaire, CNRS UMR 6547 GEEM, Université Blaise Pascal, 24, avenue des Landais, 63177 Aubière cedex, France
2 Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9050, USA
(Requests for offprints should be addressed to J R Drevet; Email: joel.drevet{at}geem.univ-bpclermont.fr)
* (J-M Frenoux and P Vernet contributed equally to this work)
In this study we looked at the epididymides and spermatozoa of mice knocked-out for nuclear oxysterol receptors (LXR). We have shown that LXR-deficient mice exhibited upon ageing a severe disruption of their caput epididymides associated with abnormal accumulation of neutral lipids. The epididymis defaults were correlated with sperm head fragility and infertility. In agreement with the observed caput defect in transgenic animals in which both LXR
and LXRß isoforms were disrupted, we have shown here that both receptors are expressed in caput and cauda epididymides regions. LXRß was predominantly expressed throughout the mouse epididymis while the expression of LXR was weaker. In addition, the expression of selected genes that can be considered as markers of adult epididymis function was monitored via Northern blots in the different single and double LXR-deficient backgrounds. Altogether, the data presented here suggest that LXR receptors are important actors in epididymis function.
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