The mammalian nucleus has considerable control over nascent transcripts. The basic mechanisms of post-transcriptional processing are well understood and recently some of the principles underlying the regulation of nuclear processing events have been elucidated. Here we review the recent progress in identification of signalling pathways that modulate the action of key RNA-binding proteins which regulate splicing, and the mechanisms of action of the C-terminal domain of RNA polymerase II that co-ordinate transcription with nuclear mRNA processing events.

This article has been cited by other articles:

				S. A. Akker, S. Misra, S. Aslam, E. L. Morgan, P. J. Smith, B. Khoo, and S. L. Chew Pre-Spliceosomal Binding of U1 Small Nuclear Ribonucleoprotein (RNP) and Heterogenous Nuclear RNP E1 Is Associated with Suppression of a Growth Hormone Receptor Pseudoexon Mol. Endocrinol., October 1, 2007; 21(10): 2529 - 2540. [Abstract] [Full Text] [PDF]

				M. J. Pinho, V. Pinto, M. P. Serrao, P. A. Jose, and P. Soares-da-Silva Underexpression of the Na+-dependent neutral amino acid transporter ASCT2 in the spontaneously hypertensive rat kidney Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R538 - R547. [Abstract] [Full Text] [PDF]

				L. W. Harries, S. Ellard, A. Stride, The European MODY consortium, N. G. Morgan, and A. T. Hattersley Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes Hum. Mol. Genet., July 15, 2006; 15(14): 2216 - 2224. [Abstract] [Full Text] [PDF]

				L. Florea Bioinformatics of alternative splicing and its regulation Brief Bioinform, March 1, 2006; 7(1): 55 - 69. [Abstract] [Full Text] [PDF]

				A. Velazquez-Dones, J. C. Hagopian, C.-T. Ma, X.-Y. Zhong, H. Zhou, G. Ghosh, X.-D. Fu, and J. A. Adams Mass Spectrometric and Kinetic Analysis of ASF/SF2 Phosphorylation by SRPK1 and Clk/Sty J. Biol. Chem., December 16, 2005; 280(50): 41761 - 41768. [Abstract] [Full Text] [PDF]

				S. Danzi and I. Klein Posttranscriptional regulation of myosin heavy chain expression in the heart by triiodothyronine Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H455 - H460. [Abstract] [Full Text] [PDF]

				D. Auboeuf, D. H. Dowhan, Y. K. Kang, K. Larkin, J. W. Lee, S. M. Berget, and B. W. O'Malley Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes PNAS, February 24, 2004; 101(8): 2270 - 2274. [Abstract] [Full Text] [PDF]

				E. H. Margulies, M. Blanchette, NISC Comparative Sequencing Program, D. Haussler, and E. D. Green Identification and Characterization of Multi-Species Conserved Sequences Genome Res., December 1, 2003; 13(12): 2507 - 2518. [Abstract] [Full Text] [PDF]

				K. A. Marfatia, E. B. Crafton, D. M. Green, and A. H. Corbett Domain Analysis of the Saccharomyces cerevisiae Heterogeneous Nuclear Ribonucleoprotein, Nab2p. DISSECTING THE REQUIREMENTS FOR Nab2p-FACILITATED POLY(A) RNA EXPORT J. Biol. Chem., February 21, 2003; 278(9): 6731 - 6740. [Abstract] [Full Text] [PDF]

				D. M. Green, C. P. Johnson, H. Hagan, and A. H. Corbett The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export PNAS, February 4, 2003; 100(3): 1010 - 1015. [Abstract] [Full Text] [PDF]

				R. Daoud, G. Mies, A. Smialowska, L. Olah, K.-A. Hossmann, and S. Stamm Ischemia Induces a Translocation of the Splicing Factor tra2-beta 1 and Changes Alternative Splicing Patterns in the Brain J. Neurosci., July 15, 2002; 22(14): 5889 - 5899. [Abstract] [Full Text] [PDF]

				Y. S. Lin, A. L. S. Dowling, S. D. Quigley, F. M. Farin, J. Zhang, J. Lamba, E. G. Schuetz, and K. E. Thummel Co-Regulation of CYP3A4 and CYP3A5 and Contribution to Hepatic and Intestinal Midazolam Metabolism Mol. Pharmacol., July 1, 2002; 62(1): 162 - 172. [Abstract] [Full Text] [PDF]

				C. P. Leo, S. Y. Hsu, and A. J. W. Hsueh Hormonal Genomics Endocr. Rev., June 1, 2002; 23(3): 369 - 381. [Abstract] [Full Text] [PDF]

				D. M. Green, K. A. Marfatia, E. B. Crafton, X. Zhang, X. Cheng, and A. H. Corbett Nab2p Is Required for Poly(A) RNA Export in Saccharomyces cerevisiae and Is Regulated by Arginine Methylation via Hmt1p J. Biol. Chem., March 1, 2002; 277(10): 7752 - 7760. [Abstract] [Full Text] [PDF]