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We have cloned a full length cDNA coding for activin β_B subunit from the goldfish ovary. Sequence analysis of the goldfish activin β_B shows that this peptide is extremely conserved across vertebrates. The mature region of goldfish activin β_B has 93 and 98% amino acid identity with that of human and zebrafish β_B subunit respectively. The identity of the cloned goldfish activin β_B was further confirmed by expressing the protein in the Chinese hamster ovary (CHO) cells followed by detection of the specific activity of activin in the culture medium using F5-5 cell assay. mRNA of goldfish activin βB is expressed in a variety of goldfish tissues including ovary, testis, brain, pituitary, kidney and liver, suggesting a wide range of physiological roles for activin in the goldfish.

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				G. F Y Cheng, C.-W. Yuen, and W. Ge Evidence for the existence of a local activin follistatin negative feedback loop in the goldfish pituitary and its regulation by activin and gonadal steroids J. Endocrinol., December 1, 2007; 195(3): 373 - 384. [Abstract] [Full Text] [PDF]

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