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Steroid hormones generally mediate their effects by interacting with specific receptors which then bind to defined DNA sequences in the regulatory regions of target genes to activate expression (see Gronmeyer (1992) and references therein). However, the post-transcriptional regulation of gene expression by steroid hormones is also well documented (see Nielsen & Shapiro 1990). Indeed steroid hormones were amongst the first agents to be demonstrated to play a role in mRNA stabilization (Palmiter & Carey 1974). For example, glucocorticoid hormones have been shown to enhance the stability of growth hormone mRNA (Paek & Axel 1987), testosterone has been reported to induce changes in the poly(A) tail length of the mRNA encoding cystatin-related protein (Vercaeren et al. 1992) and testosterone and/or oestrogen induce changes in the poly(A) tail length of the vasopressin mRNA (Carter & Murphy 1993) associated with changes in mRNA accumulation. However, it is still unclear how steroids mediate these

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