HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wong, M Articles by Parker, K L Search for Related Content PubMed PubMed Citation Articles by Wong, M Articles by Parker, K L

The orphan nuclear receptor steroidogenic factor 1 (SF-1) plays key roles in endocrine development and function. Initially identified as a positive regulator of the cytochrome P450 steroid hydroxylases, analyses of knockout mice deficient in SF-1 revealed that SF-1 is essential for adrenal and gonadal development, pituitary gonadotropin expression and formation of the ventromedial hypothalamic nucleus. Although more limited in scope, analyses of SF-1 in humans similarly have suggested that SF-1 is important for differentiated function in adrenocortical and gonadotrope adenomas. In the hope of extending our understanding of SF-1 function by identifying possible roles of SF-1 in clinical endocrine disorders, we isolated the FTZ-F1 gene encoding human SF-1 and mapped it to chromosome 9q33. In this report, we characterize the sequence and structural organization of the human cDNA and gene encoding SF-1, providing new insights into comparative aspects of SF-1 structure that will facilitate efforts to study the role of this transcription factor in human endocrine disorders.

This article has been cited by other articles:

				M. Dumic, K. Lin-Su, N. I. Leibel, S. Ciglar, G. Vinci, R. Lasan, S. Nimkarn, J. D. Wilson, K. McElreavey, and M. I. New Report of Fertility in a Woman with a Predominantly 46,XY Karyotype in a Family with Multiple Disorders of Sexual Development J. Clin. Endocrinol. Metab., January 1, 2008; 93(1): 182 - 189. [Abstract] [Full Text] [PDF]

				A. L Reuter, K. Goji, N. C Bingham, M. Matsuo, and K. L Parker A novel mutation in the accessory DNA-binding domain of human steroidogenic factor 1 causes XY gonadal dysgenesis without adrenal insufficiency Eur. J. Endocrinol., August 1, 2007; 157(2): 233 - 238. [Abstract] [Full Text] [PDF]

				R. Coutant, D. Mallet, N. Lahlou, N. Bouhours-Nouet, A. Guichet, L. Coupris, A. Croue, and Y. Morel Heterozygous Mutation of Steroidogenic Factor-1 in 46,XY Subjects May Mimic Partial Androgen Insensitivity Syndrome J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 2868 - 2873. [Abstract] [Full Text] [PDF]

				L. Lin, P. Philibert, B. Ferraz-de-Souza, D. Kelberman, T. Homfray, A. Albanese, V. Molini, N. J. Sebire, S. Einaudi, G. S. Conway, et al. Heterozygous Missense Mutations in Steroidogenic Factor 1 (SF1/Ad4BP, NR5A1) Are Associated with 46,XY Disorders of Sex Development with Normal Adrenal Function J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 991 - 999. [Abstract] [Full Text] [PDF]

				G. Benoit, A. Cooney, V. Giguere, H. Ingraham, M. Lazar, G. Muscat, T. Perlmann, J.-P. Renaud, J. Schwabe, F. Sladek, et al. International Union of Pharmacology. LXVI. Orphan Nuclear Receptors Pharmacol. Rev., December 1, 2006; 58(4): 798 - 836. [Abstract] [Full Text] [PDF]

				L. Lin, W.-X. Gu, G. Ozisik, W. S. To, C. J. Owen, J. L. Jameson, and J. C. Achermann Analysis of DAX1 (NR0B1) and Steroidogenic Factor-1 (NR5A1) in Children and Adults with Primary Adrenal Failure: Ten Years' Experience J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 3048 - 3054. [Abstract] [Full Text] [PDF]

				R. V. Correa, S. Domenice, N. C. Bingham, A. E. C. Billerbeck, W. E. Rainey, K. L. Parker, and B. B. Mendonca A Microdeletion in the Ligand Binding Domain of Human Steroidogenic Factor 1 Causes XY Sex Reversal without Adrenal Insufficiency J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1767 - 1772. [Abstract] [Full Text] [PDF]

				F. Gizard, B. Lavallee, F. DeWitte, E. Teissier, B. Staels, and D. W. Hum The Transcriptional Regulating Protein of 132 kDa (TReP-132) Enhances P450scc Gene Transcription through Interaction with Steroidogenic Factor-1 in Human Adrenal Cells J. Biol. Chem., October 11, 2002; 277(42): 39144 - 39155. [Abstract] [Full Text] [PDF]

				J. C. Achermann, G. Ozisik, M. Ito, U. A. Orun, K. Harmanci, B. Gurakan, and J. L. Jameson Gonadal Determination and Adrenal Development Are Regulated by the Orphan Nuclear Receptor Steroidogenic Factor-1, in a Dose-Dependent Manner J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1829 - 1833. [Abstract] [Full Text] [PDF]

				K. L. Parker, D. A. Rice, D. S. Lala, Y. Ikeda, X. Luo, M. Wong, M. Bakke, L. Zhao, C. Frigeri, N. A. Hanley, et al. Steroidogenic Factor 1: an Essential Mediator of Endocrine Development Recent Prog. Horm. Res., January 1, 2002; 57(1): 19 - 36. [Abstract] [Full Text] [PDF]

				N. A. Hanley, W. E. Rainey, D. I. Wilson, S. G. Ball, and K. L. Parker Expression Profiles of SF-1, DAX1, and CYP17 in the Human Fetal Adrenal Gland: Potential Interactions in Gene Regulation Mol. Endocrinol., January 1, 2001; 15(1): 57 - 68. [Abstract] [Full Text]

				IMAGe, a New Clinical Association of Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, and Genital Anomalies J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4335 - 4340. [Abstract] [Full Text]

				Adrenal Hyperandrogenism in Children J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4431 - 4435. [Full Text]

				L.-A. Li, E. F-L. Chiang, J.-C. Chen, N.-C. Hsu, Y.-J. Chen, and B.-c. Chung Function of Steroidogenic Factor 1 Domains in Nuclear Localization, Transactivation, and Interaction with Transcription Factor TFIIB and c-Jun Mol. Endocrinol., September 1, 1999; 13(9): 1588 - 1598. [Abstract] [Full Text]

				M. Li, Y.-H. Xie, Y.-Y. Kong, X. Wu, L. Zhu, and Y. Wang Cloning and Characterization of a Novel Human Hepatocyte Transcription Factor, hB1F, Which Binds and Activates Enhancer II of Hepatitis B Virus J. Biol. Chem., October 30, 1998; 273(44): 29022 - 29031. [Abstract] [Full Text] [PDF]

				N. Pilon, R. Behdjani, I. Daneau, J. G. Lussier, and D. W. Silversides Porcine Steroidogenic Factor-1 Gene (pSF-1) Expression and Analysis of Embryonic Pig Gonads during Sexual Differentiation Endocrinology, September 1, 1998; 139(9): 3803 - 3812. [Abstract] [Full Text] [PDF]

				K. L. Parker and B. P. Schimmer Steroidogenic Factor 1: A Key Determinant of Endocrine Development and Function Endocr. Rev., June 1, 1997; 18(3): 361 - 377. [Abstract] [Full Text]

				M. S. Ramayya, J. Zhou, T. Kino, J. H. Segars, C. A. Bondy, and G. P. Chrousos Steroidogenic Factor 1 Messenger Ribonucleic Acid Expression in Steroidogenic and Nonsteroidogenic Human Tissues: Northern Blot and in Situ Hybridization Studies J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1799 - 1806. [Abstract] [Full Text] [PDF]

				A. C. Latronico and G. P. Chrousos Adrenocortical Tumors J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1317 - 1324. [Full Text] [PDF]