HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Delhase, M Articles by Hooghe-Peters, E L Search for Related Content PubMed PubMed Citation Articles by Delhase, M Articles by Hooghe-Peters, E L

Adenomas can develop from each cell type of the anterior pituitary. In the normal pituitary, three of these cell types, the GH-, prolactin- and TSH-secreting cells, express the transcription factor Pit-1/GHF-1 which is responsible for prolactin and GH (and probably TSH) cell commitment, differentiation, probably proliferation and gene expression. We have analysed the expression of Pit-1/GHF-1 in a panel of human pituitary adenomas. All GH-, prolactin- and TSH-expressing adenomas studied expressed the Pit-1/GHF-1 factor, as demonstrated by in-situ hybridization and immunocytochemistry. The expression was higher in adenomas than in normal human pituitary. In contrast, ACTH- and LH—FSH-secreting and non-secreting adenomas were negative. Seven transplants of the spontaneous rat prolactinoma SMtTW were also investigated and all were found to be positive.

This further stresses the analogy between these tumours and human prolactinomas. Taken together, the data confirm that Pit-1/GHF-1 expression is restricted to GH-, prolactin- and TSH-expressing cells, and the increased expression in adenomas is compatible with a role of Pit-1/GHF-1 in cell proliferation.

This article has been cited by other articles:

				I. Pellegrini, C. Roche, M.-H. Quentien, M. Ferrand, G. Gunz, S. Thirion, C. Bagnis, A. Enjalbert, and J.-L. Franc Involvement of the Pituitary-Specific Transcription Factor Pit-1 in Somatolactotrope Cell Growth and Death: An Approach Using Dominant-Negative Pit-1 Mutants Mol. Endocrinol., December 1, 2006; 20(12): 3212 - 3227. [Abstract] [Full Text] [PDF]

				S. Seoane and R. Perez-Fernandez The Vitamin D Receptor Represses Transcription of the Pituitary Transcription Factor Pit-1 Gene without Involvement of the Retinoid X Receptor Mol. Endocrinol., April 1, 2006; 20(4): 735 - 748. [Abstract] [Full Text] [PDF]

				C Gil-Puig, S Seoane, M Blanco, M Macia, T Garcia-Caballero, C Segura, and R Perez-Fernandez Pit-1 is expressed in normal and tumorous human breast and regulates GH secretion and cell proliferation Eur. J. Endocrinol., August 1, 2005; 153(2): 335 - 344. [Abstract] [Full Text] [PDF]