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The results of this study suggest that the atypical β-adrenergic receptor (β₃ subtype) is expressed in human white adipose tissue. A β₃-adrenergic receptor mRNA could be detected in human omental fat poly(A)⁺ RNA by polymerase chain reaction amplification with appropriate primers. The expression of the β₃-adrenergic receptor in human fat was confirmed by Northern blot analysis; however, the level of its mRNA was lower than those of the β₁- and β₂-adrenergic receptors. Two populations of ((–)-4-(3-t-butylamino-2-hydroxypropoxy)-[5,7-³H]benz-imidazole-2-one) ([³H]CGP 12177)-binding sites were identified in human omental fat membranes, one with a high affinity (K_d= 1·7 nM) and the other with a low affinity (K_d = 22 nM). The low affinity binding site population, which should represent the β₃-adrenergic receptor, was predominant (75% of the total binding sites).

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